All CLIMB research are designed for answering a scientific question ‘How genetic and other factors impact the lifespan development of human brain and mind?‘. Brain connectomics has enhanced our understanding of neurocognitive development and decline by the integration of network sciences into studies across different stages of the human life span. To pursue the opportunity to test integrated models of the dynamical brain organization across the entire life span, we target a national lifespan cohort on development of human brain and mind, namely Chinese Color Nest Project (CCNP). With the success of building up this cohort, we will develop a novel computational and neuroinformatic platform, Connectome Computation System (CCS) for CCNP, for modeling a set of normative trajectories of the human brain and its mind/behavior associations. To build up such a system, reliability and reproducibility is the most critical base and motivate the team to focus its methodology research on reliability and reproducibility of the measurements of human brain and mind. With more than 10-years experiences of reliability studies with resting-state FMRI, the team launched an international effort on reliability and reproducibility, building up the Consortium for Reliability and Reproducibility (CoRR). The whole framework has a name climb-C3 and can be divided into to the above three parts, which accounts for the research on lifespan cohort, computational system as well as reliability and reproducibility, respectively.